diff --git a/src/libraries/System.Net.Sockets/src/System/Net/Sockets/Socket.cs b/src/libraries/System.Net.Sockets/src/System/Net/Sockets/Socket.cs
index f3faf63b036df1..fb8367f258e81a 100644
--- a/src/libraries/System.Net.Sockets/src/System/Net/Sockets/Socket.cs
+++ b/src/libraries/System.Net.Sockets/src/System/Net/Sockets/Socket.cs
@@ -1356,7 +1356,7 @@ public int SendTo(byte[] buffer, int offset, int size, SocketFlags socketFlags,
             ThrowIfDisposed();
 
             ValidateBufferArguments(buffer, offset, size);
-            ArgumentNullException.ThrowIfNull(remoteEP);
+            ValidateSendToEndpointAndState(remoteEP, nameof(remoteEP));
 
             ValidateBlockingMode();
             if (NetEventSource.Log.IsEnabled()) NetEventSource.Info(this, $"SRC:{LocalEndPoint} size:{size} remoteEP:{remoteEP}");
@@ -1439,7 +1439,7 @@ public int SendTo(ReadOnlySpan<byte> buffer, SocketFlags socketFlags, EndPoint r
             if (!Socket.OSSupportsThreads) throw new PlatformNotSupportedException(); // TODO remove with https://github.com/dotnet/runtime/pull/107185
 
             ThrowIfDisposed();
-            ArgumentNullException.ThrowIfNull(remoteEP);
+            ValidateSendToEndpointAndState(remoteEP, nameof(remoteEP));
 
             ValidateBlockingMode();
 
@@ -3280,6 +3280,11 @@ private bool SendToAsync(SocketAsyncEventArgs e, CancellationToken cancellationT
                 throw new ArgumentException(SR.Format(SR.InvalidNullArgument, "e.RemoteEndPoint"), nameof(e));
             }
 
+            if (endPointSnapshot is not null && !CanTryAddressFamily(endPointSnapshot.AddressFamily))
+            {
+                throw new ArgumentException(SR.Format(SR.net_InvalidEndPointAddressFamily, endPointSnapshot.AddressFamily, _addressFamily), nameof(e));
+            }
+
             if (e._socketAddress != null && endPointSnapshot is IPEndPoint ipep && e._socketAddress.Family == endPointSnapshot?.AddressFamily)
             {
                 // we have matching SocketAddress. Since this is only used internally, it is ok to overwrite it without
@@ -3987,6 +3992,24 @@ private void ValidateReceiveFromEndpointAndState(EndPoint remoteEndPoint, string
             }
         }
 
+        // Validates that the remoteEndPoint is compatible with the Socket so that a SendTo call won't fail deep
+        // inside the OS PAL with a SocketError.InvalidArgument. This mirrors the address-family guard already
+        // applied to the ReceiveFrom/ReceiveMessageFrom methods so the SendTo family behaves consistently.
+        private void ValidateSendToEndpointAndState(EndPoint remoteEndPoint, string remoteEndPointArgumentName)
+        {
+            ArgumentNullException.ThrowIfNull(remoteEndPoint, remoteEndPointArgumentName);
+
+            if (remoteEndPoint is DnsEndPoint)
+            {
+                throw new ArgumentException(SR.Format(SR.net_sockets_invalid_dnsendpoint, remoteEndPointArgumentName), remoteEndPointArgumentName);
+            }
+
+            if (!CanTryAddressFamily(remoteEndPoint.AddressFamily))
+            {
+                throw new ArgumentException(SR.Format(SR.net_InvalidEndPointAddressFamily, remoteEndPoint.AddressFamily, _addressFamily), remoteEndPointArgumentName);
+            }
+        }
+
         // ValidateBlockingMode - called before synchronous calls to validate
         // the fact that we are in blocking mode (not in non-blocking mode) so the
         // call will actually be synchronous.
diff --git a/src/libraries/System.Net.Sockets/tests/FunctionalTests/DualModeSocketTest.cs b/src/libraries/System.Net.Sockets/tests/FunctionalTests/DualModeSocketTest.cs
index 57f180f8eccd56..7858683c6fe25e 100644
--- a/src/libraries/System.Net.Sockets/tests/FunctionalTests/DualModeSocketTest.cs
+++ b/src/libraries/System.Net.Sockets/tests/FunctionalTests/DualModeSocketTest.cs
@@ -880,9 +880,11 @@ protected DualModeConnectionlessSendToBase(ITestOutputHelper output) : base(outp
         [Fact]
         public async Task Socket_SendToV4IPEndPointToV4Host_Throws()
         {
+            // "The supplied EndPoint of AddressFamily InterNetwork is not valid for this Socket, use InterNetworkV6 instead."
+            // https://github.com/dotnet/runtime/issues/47772
             using Socket socket = new Socket(SocketType.Dgram, ProtocolType.Udp);
             socket.DualMode = false;
-            await Assert.ThrowsAsync<SocketException>(
+            await Assert.ThrowsAsync<ArgumentException>(
                 () => SendToAsync(socket, new byte[1], new IPEndPoint(IPAddress.Loopback, DualModeBase.UnusedPort)));
         }
 
diff --git a/src/libraries/System.Net.Sockets/tests/FunctionalTests/SendTo.cs b/src/libraries/System.Net.Sockets/tests/FunctionalTests/SendTo.cs
index 116053d971e989..930cebf2e80674 100644
--- a/src/libraries/System.Net.Sockets/tests/FunctionalTests/SendTo.cs
+++ b/src/libraries/System.Net.Sockets/tests/FunctionalTests/SendTo.cs
@@ -74,6 +74,21 @@ public async Task NullSocketAddress_Throws_ArgumentException()
             await AssertThrowsSynchronously<ArgumentNullException>(() => socket.SendToAsync(new byte[1], SocketFlags.None, socketAddress).AsTask());
         }
 
+        // https://github.com/dotnet/runtime/issues/47772
+        // SendTo should validate the remote end point's address family up front (like ReceiveFrom does)
+        // instead of failing deep inside the OS PAL with a SocketError.InvalidArgument.
+        [Fact]
+        public async Task AddressFamilyDoesNotMatch_Throws_ArgumentException()
+        {
+            using var ipv4Socket = CreateSocket();
+            EndPoint ipV6Endpoint = GetGetDummyTestEndpoint(AddressFamily.InterNetworkV6);
+            await AssertThrowsSynchronously<ArgumentException>(() => SendToAsync(ipv4Socket, new ArraySegment<byte>(new byte[1]), ipV6Endpoint));
+
+            // The synchronous byte[] and span overloads must behave consistently as well.
+            Assert.Throws<ArgumentException>(() => ipv4Socket.SendTo(new byte[1], ipV6Endpoint));
+            Assert.Throws<ArgumentException>(() => ipv4Socket.SendTo(new byte[1].AsSpan(), SocketFlags.None, ipV6Endpoint));
+        }
+
         [Fact]
         public async Task Datagram_UDP_ShouldImplicitlyBindLocalEndpoint()
         {